Symbolically, this aspect is represented by the National Museum of Science and Technology.
The museum, which is spread over an area of 40,000 square meters, is representative of the entire works of the human scientific and technological ingenuity in every age; it is the biggest science and technology museum in Italy and owns the largest collection in the world of machine models made from drawings by Leonardo da Vinci. 15,000 technical scientific and artistic assets are the collections of the Museum: collected from the years 30 'of the twentieth century are representative of the history of the Italian science, technology and industry from the nineteenth up today. They include scientific and technical apparatus and instruments, machinery and equipment also of big dimensions, in particular on the means of transport (road, marine, rail, air), energy production, the steel industry, the history of telecommunications and computer science, astronautics.
The Leonardo da Vinci Gallery exhibits different historical models of machines designed by Leonardo da Vinci in the pages of the famous codes, ranging from civil, as the crane swivel or machine pile driver, and military, as fast ship ramming, studies on 'architecture, with the model of the ideal city and those on the flight, with the famous aerial screw. It is also visible an automatic wooden loom , life-sized and fully functional, made from studies on the codices.

Then there are a series of rooms dedicated to specific disciplines: Clocks, Telecommunications (with a room dedicated to the radio and Guglielmo Marconi), Sound and acoustic, Musical Instruments, Astronomy (model with the Foucault pendulum), Land Transport (carriages, cars, motorcycles and bicycles), graphic arts, papermaking and printing, production of energy, metallurgy and metal (with a mill of 1867), Art of jewelry, steel processing, polymer materials (glues and substances adhesive, rubber, plastics), life cycle of products.

A Pavilion develops the theme of navigation, both on the sea and in the skies, both civilian and military. There are in fact heirlooms of ancient warships and some media assault ship and air used in the two world wars. In the collection stand out some prestigious pieces including one of only three surviving examples of hunting Macchi MC205V Veltro used during the Second World War, the school ship Ebe of the Italian Navy (it is a wooden sailing ship launched in 1921), one section of the liner Conte Biancamano including the bridge, some first class cabins and the ballroom, the submarine Enrico Toti.

A Pavilion of the railway is realistically designed as a real railway station full of the characteristic noise with rails docks and railway signals. Inside the pavilion are preserved many original pieces and it includes steam locomotives electric Diesel national and foreign.

In the building of the Museum are visible ruins of the wall of the imperial mausoleum and tombs dating back to the late Imperial Roman times, witnessing the splendor of the period when Milan became the capital of the Roman Empire. In particular there is the oldest Christian inscription found in Milan dated 368 AD at the time of Valentinian I.